WebAug 12, 2024 · Cinacalcet is a “calcimimetic,” meaning that it acts on the calcium-sensing receptors (CaSR) located on the chief cells of the parathyroid gland. [8] CaSR detects a minor change in the extracellular calcium level and maintains the PTH level accordingly. [8] This process occurs through PTH gene transcription and parathyroid cell growth. WebJan 26, 2024 · Cinacalcet Accordpharma is a medicine used to treat: secondary hyperparathyroidism (overactive parathyroid glands) in adults and children aged 3 years and older with serious kidney disease who need dialysis (to clear their blood of waste products); hypercalcaemia (high blood calcium levels) in adults with cancer of the parathyroid …
Cinacalcet: Package Insert - Drugs.com
WebDec 10, 2024 · Background Etelcalcetide is the first intravenously administered calcimimetic agent used to manage secondary hyperparathyroidism (SHPT) in hemodialysis (HD) patients. We evaluated the safety and efficacy of replacing cinacalcet with etelcalcetide in HD patients. Methods One hundred and thirty-three patients HD on cinacalcet were … WebAbstract. Oral cinacalcet hydrochloride (HCl) [Sensipar, Mimpara] is the first in a new class of therapeutic agents, the calcimimetics, and has a novel mechanism of action. It directly modulates the principal regulator of parathyroid hormone (PTH) secretion, namely the calcium-sensing receptor (CaR) on the chief cells in the parathyroid gland. graduate advising ucsc
Sensipar (cinacalcet) dosing, indications, interactions, …
WebSensipar is indicated for the treatment of secondary hyperparathyroidism (HPT) inadultpatients with chronic kidney disease (CKD) on dialysis [see Clinical Studies … WebNov 3, 2012 · Cinacalcet and Cardiovascular Disease n engl j med 367;26 nejm.org december 27, 2012 2485 patients were taking a study drug. Three prespeci-fied interim analyses were conducted by Frontier WebSensipar is indicated for the treatment of secondary hyperparathyroidism (HPT) inadultpatients with chronic kidney disease (CKD) on dialysis [see Clinical Studies (14.1)]. Limitations of Use: Sensipar is not indicated for use in patients with CKD who arenot ondialysisbecause of an increasedrisk of hypocalcemia[see Warnings and Precautions … chimes ginger chews calories