Cisplatin induced nephrotoxicity mechanism
WebCisplatin-induced nephrotoxicity is a major adverse event (AE), and the incident rate is approximately 30%. 1 - 3 Three basic mechanisms lead to cisplatin-induced nephrotoxicity, that is, tubular cell toxicity, renal microvasculature vasoconstriction, and proinflammatory effects. 3 Several factors are associated with increased risk of … WebOct 29, 2024 · There is evidence though that necrosis, oxidative stress, inflammation, and apoptosis may play crucial roles in cisplatin-induced nephrotoxicity 5. Cisplatin-induced nephrotoxicity...
Cisplatin induced nephrotoxicity mechanism
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WebCisplatin (cis-diamminedichloroplatinum (II), DDP) is an antineoplastic agent widely used in the treatment of solid tumors because of its extensive cytotoxic activity. However, the main limiting side effect of DDP use is nephrotoxicity, a rapid deterioration in kidney function due to toxic chemicals. Several studies have shown that epigenetic processes are involved in … WebCisplatin is a widely used and highly effective cancer chemotherapeutic agent. One of the limiting side effects of cisplatin use is nephrotoxicity. Research over the past 10 years …
WebFeb 2, 2024 · The mechanisms of cisplatin-induced acute kidney injury (AKI) are complex, and there are limited renoprotective approaches. Leonurine is the main active compound of a Chinese herb and has recently been … WebMar 13, 2024 · Background: Cisplatin (cis-diamminedichloroplatinum II, CDDP) is one of the most effective chemotherapeutic agents. However, its clinical use is limited due to the …
WebThe proteinuria associated with cisplatin nephrotoxicity is attributed to a tubular defect. 32 Hemolytic uremic syndrome has also been described, especially when cisplatin is combined with bleomycin. 33 Sequential … WebMar 9, 2024 · The mechanism summary of cisplatin-induced nephrotoxicity. The mechanisms mainly include the transport and metabolism of cisplatin, apoptosis, autophagy, DNA damage, oxidative stress, and inflammation, which work together to aggravate AKI induced by cisplatin.
Webrotection against gentamicin-induced nephrotoxicity in rats (Sandhya et al. 1995). Interestingly, the dose of an antioxi-dant lipoic acid (0.12–0.48 mmole/kg) required to …
WebOct 11, 2024 · Experimentally induced sepsis (via LPS) also potentiates the degree of cisplatin-induced hearing loss in mice (Oh et al., 2011). LPS-induced inflammation in … canterbury bankstown idcanterbury bankstown footballWebJan 3, 2024 · Chemotherapy nephrotoxicity and dose modification in patients with kidney impairment: Molecularly targeted agents and immunotherapies; Cisplatin nephrotoxicity; Classic Kaposi sarcoma: Clinical features, staging, diagnosis, and treatment; Contrast-associated and contrast-induced acute kidney injury: Clinical features, diagnosis, and … flash becoming deathhttp://www.bccancer.bc.ca/drug-database-site/Drug%20Index/Cisplatin_monograph.pdf canterbury bankstown historyWebCis-dichlorodiammine platinum (II), or cisplatin, is currently among the most widely used agents in the chemotherapy of cancer. The chief limit to its greater efficacy is its … canterbury bankstown have your sayWebSep 27, 2024 · Cisplatin induces cancer cell death by binding to the N7 reactive center of purine residues and causes irreversible DNA damage in cancer cells during division ( Dasari and Tchounwou, 2014 ), thus blocking cell division and promoting apoptosis. canterbury bankstown local business awardsWebOct 26, 2024 · Background . Cisplatin is a powerful chemotherapeutic drug mainly used in the treatment of solid tumors. Aggregation of the drug in renal proximal tubule cells causes nephrotoxicity and renal failure. Investigations showed nephrotoxicity as Cisplatin’s dose-limiting side effect. One of the Cisplatin toxicity mechanisms is generation of … flash bedroom eyes