Cyclophosphamide cardiomyopathy
WebSep 29, 2024 · Certain medications (eg, cyclophosphamide) used to treat SSc can result in cardiac toxicity. This topic will focus on the pathogenesis, epidemiology, clinical … WebAug 19, 2024 · Cyclophosphamide has a molecular formula of C 7 H 15 Cl 2 N 2 O 2 P•H 2 O and a molecular weight of 279.1. Cyclophosphamide is soluble in water, saline, or ethanol. Cyclophosphamide for Injection, USP is a sterile white cake available as 500 mg, 1 g, and 2 g strength vials.
Cyclophosphamide cardiomyopathy
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WebAbstract Acute decompensating cardiomyopathy induced by cyclophosphamide is usually irreversible. To investigate the clinical course and the outcome of therapy, 13 patients (1.7%) with grade III acute cardiomyopathy and hypotension who were treated with ablative transplant regimens between January 1980 and September 1995 were analyzed. Web(A) Cyclophosphamide 3. After several cycles of chemotherapy, the patient was found to have a high resting pulse rate. A noninvasive radionuclide scan revealed evidence of cardiomyopathy. The drug that is most likely responsible for the cardiac toxicity is …
WebFeb 21, 2024 · The clinical features of fatal cyclophosphamide-induced cardiotoxicity in a conditioning regimen for allogeneic hematopoietic stem cell transplantation (allo-HSCT). Ann Hematol 2016; 95:1145. WebSep 29, 2024 · Certain medications (eg, cyclophosphamide) used to treat SSc can result in cardiac toxicity. This topic will focus on the pathogenesis, epidemiology, clinical manifestations, diagnosis/screening, and management of cardiac involvement in SSc. Other clinical manifestations of SSc are described in detail separately.
WebThis patient with a history of bronchial asthma developed a right putaminal hemorrhage caused by EGPA. Although intravenous cyclophosphamide (IVCY) and mepolizumab (MPZ) induced remission, relapse was frequently observed. Subsequently, he developed cardiomyopathy despite administration of rituximab (RTX) substituted from IVCY and … WebA 17-year-old man with mediastinal seminoma was treated with chemotherapy and mediastinal irradiation therapy. Then he received high-dose chemotherapy containing …
WebMar 7, 2024 · Chemotherapies often administered with anthracyclines, including trastuzumab, taxanes, and cyclophosphamide, can further increase the risk of cardiotoxicity. 35 Although trastuzumab is generally well tolerated, it is associated with infrequent cardiac dysfunction, manifested most often as an asymptomatic decline in left …
WebDec 1, 2024 · There is an additive or potentially synergistic increase in the risk of cardiomyopathy in patients who have received radiotherapy to the mediastinum or concomitant therapy with other known cardiotoxic agents such as cyclophosphamide and trastuzumab. Pericarditis and myocarditis have also been reported during or following … problems installing windows updatesWebSymptoms of heart problems related to cardiotoxicity may include: Abdomen enlargement ( abdominal distension ). Chest pain. Dizziness. Heart palpitations. Shortness of breath (dyspnea). Swelling and fluid retention ( edema) in the legs. What causes cardiotoxicity? Certain cancer treatments may cause cardiotoxicity, including: regex start at beginning of lineWebApr 2, 2024 · Cardiomyopathy (kahr-dee-o-my-OP-uh-thee) is a disease of the heart muscle that makes it harder for the heart to pump blood to the rest of the body. Cardiomyopathy can lead to heart failure. The main types of cardiomyopathy include dilated, hypertrophic and restrictive cardiomyopathy. problems in stomachWebApr 30, 2024 · Cyclophosphamide is increasingly used to treat various types of cancers and autoimmune conditions. Higher doses of this drug may produce significant cardiac … regex start of lineWebAug 11, 2024 · It is a chemotherapy drug that works by slowing or stopping cell growth. Cyclophosphamide also works by decreasing your immune system 's response to … regex start and end of lineWebAug 11, 2024 · Other side effects of cyclophosphamide include: Cardiomyopathy, congestive heart failure ( CHF) (high dose) Stevens-Johnson syndrome Toxic epidermal necrolysis (rare) Hemorrhagic cystitis Absence of viable sperm in semen Low concentration of sperm in semen Interstitial pneumonia Infectious disease problems in stoicismWebMay 1, 2016 · Rituximab, cyclophosphamide, non-pegylated liposomal doxorubicin, vincristine and prednisolone (R-COMP) did not reduce acute cardiac toxicity. • N-terminal pro B-type natriuretic peptide may be an early marker of cardiac toxicity. • R-COMP had a lower infection rate compared to R-CHOP. Abstract Background problems in studying history